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Details

Stereochemistry ACHIRAL
Molecular Formula C10H10N2O
Molecular Weight 174.1992
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of EDARAVONE

SMILES

CC1=NN(C(=O)C1)C2=CC=CC=C2

InChI

InChIKey=QELUYTUMUWHWMC-UHFFFAOYSA-N
InChI=1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3

HIDE SMILES / InChI

Description

Edaravone is a free radical scavenger developed for the treatment of amyotrophic lateral sclerosis.

CNS Activity

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
RADICUT
Primary
RADICUT
PubMed

PubMed

TitleDatePubMed
Patents

Sample Use Guides

In Vivo Use Guide
30 mg of edaravone diluted with an appropriate volume of physiological saline, intravenously over 30 minutes twice a day in the morning and the evening (stroke); 60 mg of edaravone diluted with an appropriate volume of physiological saline, intravenously over 60 minutes once a day (amyotrophic lateral sclerosis).
Route of Administration: Intravenous
In Vitro Use Guide
1 uM or more of edaravone inhibited cultured vascular endothelial cell injury in vitro caused by 15-HPETE (hydroperoxyeicosatetraenoic acid).
Name Type Language
EDARAVONE
HSDB   INN   JAN   MART.   USAN   WHO-DD  
USAN   INN  
Official Name English
3H-PYRAZOL-3-ONE, 2,4-DIHYDRO-5-METHYL-2-PHENYL-
Systematic Name English
COLOREX PMP
Brand Name English
ANTIPYRINE RELATED COMPOUND A
USP-RS  
Common Name English
NORPHENAZONE [MI]
Common Name English
NSC-12
Code English
NSC-2629
Code English
C.I. DEVELOPER 1
Common Name English
NORPHENAZONE
MI  
Common Name English
DEVELOPER Z
Common Name English
RADICUT
Brand Name English
EDARAVONE [USAN]
Common Name English
EDARAVONE [HSDB]
Common Name English
EDARAVONE [WHO-DD]
Common Name English
MCI-186
Code English
1-PHENYL-3-METHYL-5-PYRAZOLONE
Systematic Name English
RADICAVA
Brand Name English
NSC-26139
Code English
JAROCOL PMP
Brand Name English
3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE
Systematic Name English
PHENYL METHYL PYRAZOLONE
INCI  
INCI  
Official Name English
ANTIPYRINE RELATED COMPOUND A [USP-RS]
Common Name English
EDARAVONE [MART.]
Common Name English
EDARAVONE [JAN]
Common Name English
PHENYLMETHYLPYRAZOLONE
Systematic Name English
PHENYL METHYL PYRAZOLONE [INCI]
Common Name English
EDARAVONE [INN]
Common Name English
Code System Code Type Description
JAPANESE REVIEW
RADICUT
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY APPROVED JUNE 2015
RXCUI
1921877
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
CAS
89-25-8
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
MESH
C005435
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
ChEMBL
CHEMBL290916
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
PUBCHEM
4021
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY SWITZERF
CAS
942-32-5
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
ALTERNATIVE
HSDB
89-25-8
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
WIKIPEDIA
EDARAVONE
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
ECHA (EC/EINECS)
201-891-0
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
INN
7362
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
EVMPD
SUB06453MIG
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
MERCK INDEX
M8072
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY Merck Index
ECHA (EC/EINECS)
213-390-4
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
ALTERNATIVE
NCI_THESAURUS
C74323
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY
EPA CompTox
942-32-5
Created by admin on Tue Mar 06 10:57:25 UTC 2018 , Edited by admin on Tue Mar 06 10:57:25 UTC 2018
PRIMARY