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Details

Stereochemistry ACHIRAL
Molecular Formula C29H33NO4
Molecular Weight 459.5766
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TRIFAROTENE

SMILES

CC(C)(C)C1=CC(=CC=C1N2CCCC2)C3=CC(=CC=C3OCCO)C4=CC=C(C=C4)C(O)=O

InChI

InChIKey=MFBCDACCJCDGBA-UHFFFAOYSA-N
InChI=1S/C29H33NO4/c1-29(2,3)25-19-23(10-12-26(25)30-14-4-5-15-30)24-18-22(11-13-27(24)34-17-16-31)20-6-8-21(9-7-20)28(32)33/h6-13,18-19,31H,4-5,14-17H2,1-3H3,(H,32,33)

HIDE SMILES / InChI

Molecular Formula C29H33NO4
Molecular Weight 459.5766
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Trifarotene is a novel first-in-class fourth-generation topical retinoid. It is a potent and selective RAR gamma-agonist. In multiple mouse models, trifarotene exhibited superior comedolytic, anti-inflammatory and depigmenting activity compared with other topical retinoids. In this 52-week study, trifarotene was safe, well-tolerated and effective in moderate facial and truncal acne. Trifarotene is in phase II clinical trial for the treatment of ichthyosis.

Originator

Approval Year

PubMed

PubMed

TitleDatePubMed
Patents
Substance Class Chemical
Created
by admin
on Tue Oct 22 01:53:02 UTC 2019
Edited
by admin
on Tue Oct 22 01:53:02 UTC 2019
Record UNII
0J8RN2W0HK
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TRIFAROTENE
INN   USAN   WHO-DD  
INN   USAN  
Official Name English
CD-5789
Code English
(1,1':3',1''-TERPHENYL)-4-CARBOXYLIC ACID, 3''-(1,1-DIMETHYLETHYL)-4'-(2-HYDROXYETHOXY)-4''-(1-PYRROLIDINYL)-
Systematic Name English
CD5789
Code English
TRIFAROTENE [INN]
Common Name English
TRIFAROTENE [USAN]
Common Name English
TRIFAROTENE [WHO-DD]
Common Name English
3''-TERT-BUTYL-4'-(2-HYDROXYETHOXY)-4''-(PYRROLIDIN-1-YL)(1,1':3',1'')TERPHENYL-4-CARBOXYLIC ACID
Systematic Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 431014
Created by admin on Tue Oct 22 01:53:02 UTC 2019 , Edited by admin on Tue Oct 22 01:53:02 UTC 2019
WHO-ATC D10AD06
Created by admin on Tue Oct 22 01:53:02 UTC 2019 , Edited by admin on Tue Oct 22 01:53:02 UTC 2019
Code System Code Type Description
CAS
895542-09-3
Created by admin on Tue Oct 22 01:53:02 UTC 2019 , Edited by admin on Tue Oct 22 01:53:02 UTC 2019
PRIMARY
INN
9582
Created by admin on Tue Oct 22 01:53:02 UTC 2019 , Edited by admin on Tue Oct 22 01:53:02 UTC 2019
PRIMARY
ChEMBL
CHEMBL3707313
Created by admin on Tue Oct 22 01:53:02 UTC 2019 , Edited by admin on Tue Oct 22 01:53:02 UTC 2019
PRIMARY
EPA CompTox
895542-09-3
Created by admin on Tue Oct 22 01:53:02 UTC 2019 , Edited by admin on Tue Oct 22 01:53:02 UTC 2019
PRIMARY
EVMPD
SUB184480
Created by admin on Tue Oct 22 01:53:02 UTC 2019 , Edited by admin on Tue Oct 22 01:53:02 UTC 2019
PRIMARY
PUBCHEM
11518241
Created by admin on Tue Oct 22 01:53:02 UTC 2019 , Edited by admin on Tue Oct 22 01:53:02 UTC 2019
PRIMARY
Related Record Type Details
ACTIVE MOIETY