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Description

Hydroxypioglitazone (M-IV) is an active metabolite of the peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone. Experiments in vitro have shown that hydroxypioglitazone was more efficient than the parent drug in stimulating lipid synthesis.

Approval Year

PubMed

PubMed

TitleDatePubMed
Synthesis and biological activity of metabolites of the antidiabetic, antihyperglycemic agent pioglitazone.
1996 Dec 20
Development and validation of highly selective and robust method for simultaneous estimation of pioglitazone, hydroxypioglitazone and metformin in human plasma by LC-MS/MS: application to a pharmacokinetic study.
2013 Jul 1
A validated liquid chromatography tandem mass spectrometry method for simultaneous determination of pioglitazone, hydroxypioglitazone, and ketopioglitazone in human plasma and its application to a clinical study.
2014 Oct 15
Substance Class
Concept
Record UNII
WN9K42SAM6
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LERIGLITAZONE HYDROCHLORIDE
USAN  
Official Name English
ALL-AMBO-5-((4-(2-(5-(1-HYDROXYETHYL)PYRIDIN-2-YL)ETHOXY)PHENYL)METHYL)-1,3-THIAZOLE-2,4(3H,5H)-DIONE HYDROCLORIDE (1:1)
Common Name English
LERIGLITAZONE HYDROCHLORIDE [USAN]
Common Name English
2,4-THIAZOLIDINEDIONE, 5-((4-(2-(5-(1-HYDROXYETHYL)-2-PYRIDINYL)ETHOXY)PHENYL)METHYL)-, HYDROCHLORIDE (1:1)
Systematic Name English
2,4-THIAZOLIDINEDIONE, 5-((4-(2-(5-(1-HYDROXYETHYL)-2-PYRIDINYL)ETHOXY)PHENYL)METHYL)-, MONOHYDROCHLORIDE
Systematic Name English
Classification Tree Code System Code
EU-Orphan Drug EU/3/16/1770
Created by admin on Mon Oct 21 20:54:50 UTC 2019 , Edited by admin on Mon Oct 21 20:54:50 UTC 2019
Code System Code Type Description
CAS
146062-46-6
Created by admin on Mon Oct 21 20:54:50 UTC 2019 , Edited by admin on Mon Oct 21 20:54:50 UTC 2019
PRIMARY
EVMPD
SUB196366
Created by admin on Mon Oct 21 20:54:50 UTC 2019 , Edited by admin on Mon Oct 21 20:54:50 UTC 2019
PRIMARY
PUBCHEM
86748889
Created by admin on Mon Oct 21 20:54:50 UTC 2019 , Edited by admin on Mon Oct 21 20:54:50 UTC 2019
PRIMARY
This is a non-substance concept
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY
This is a non-substance concept