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Approval Year

PubMed

PubMed

TitleDatePubMed
Multiple species metabolism of PHA-568487, a selective alpha 7 nicotinic acetylcholine receptor agonist.
2010 Aug
Resolving postoperative neuroinflammation and cognitive decline.
2011 Dec
Activation of α-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress.
2014
Alpha-7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress, and brain injury in mice with ischemic stroke and bone fracture.
2014 Nov
Donepezil and the alpha-7 agonist PHA 568487, but not risperidone, ameliorate spatial memory deficits in a subchronic MK-801 mouse model of cognitive impairment in schizophrenia.
2014 Oct 1
Stimulation of the α7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice.
2015 Mar 17
Reducing inflammation and rescuing FTD-related behavioral deficits in progranulin-deficient mice with α7 nicotinic acetylcholine receptor agonists.
2015 Oct 15
Activation of Alpha-7 Nicotinic Acetylcholine Receptor Reduces Brain Edema in Mice with Ischemic Stroke and Bone Fracture.
2017 Dec
α7 nicotinic acetylcholine receptor agonist inhibits the damage of rat hippocampal neurons by TLR4/Myd88/NF‑κB signaling pathway during cardiopulmonary bypass.
2017 Oct
In vivo imaging of Α7 nicotinic receptors as a novel method to monitor neuroinflammation after cerebral ischemia.
2018 Aug
Substance Class
Concept
Record UNII
XFL65583PD
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PHA-568487 FUMARATE
Common Name English
1,4-BENZODIOXIN-6-CARBOXAMIDE, N-((3R)-1-AZABICYCLO(2.2.2)OCT-3-YL)-2,3-DIHYDRO-, (2E)-2-BUTENEDIOATE (1:1)
Systematic Name English
Code System Code Type Description
CAS
527680-57-5
Created by admin on Tue Oct 22 15:05:46 UTC 2019 , Edited by admin on Tue Oct 22 15:05:46 UTC 2019
PRIMARY
This is a non-substance concept
Related Record Type Details
PARENT -> SALT/SOLVATE
This is a non-substance concept