U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Status:
Investigational
Source:
INN:ketoxal
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

KETHOXAL, a butanone derivative, has antiviral and anaplasmosis properties. It reacts with guanine to create a stable covalent adduct. KETHOXAL interacts with 30S ribosomal subunits yielding inactive ribosomes.
Status:
Investigational
Source:
INN:leniquinsin
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Leniquinsin acts as a vasodilator and shows antihypertensive effects. It is a potent rat brain phosphodiesterase inhibitor. Its hypotensive effect would seem to be due to alpha-adrenergic blockade and to a direct action on smooth muscle.
Status:
Investigational
Source:
NCT00409071: Phase 3 Breast Cancer
(2005)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Cocculine is an alkaloid found in the leaves of Cocculus laurifolius, the laurel-leaved snail tree. Cocculine has hypotensive and ganglion blocking properties.
Status:
Investigational
Source:
USAN:CHLORMERODRIN HG 203 [USAN]
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Chlormerodrin HG-203 is chlormerodrin containing the radioactive isotope hydrargyrum-203. It was formerly used as a diagnostic aid in determination of renal function.
Status:
Investigational
Source:
NCT02450890: Phase 3 Attention Deficit Hyperactivity Disorder
(2015)
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Oradon was developed as a mercurial diuretic for oral administration. Information about the current use of this drug is not available.
Status:
Investigational
Source:
USAN:TRIAMCINOLONE ACETONIDE SODIUM PHOSPHATE [USAN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Triamcinolone acetonide- 21-dihydrogen phosphate is the long-acting derivative of a synthetic glucocorticoid triamcinolone. Triamcinolone acetonide has eight times more potency than prednisolone. Triamcinolone acetonide- 21-dihydrogen phosphate used for intravenous injection. It is supposed to be hydrolyzed rapidly in the body to form the free corticoid alcohol.
Status:
Investigational
Source:
INN:flumezapine
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

FLUMEZAPINE, a benzodiazepine derivative, is an antipsychotic agent. It is a potent blocker of dopamine D2 and of some serotonin receptors. Its clinical development was dropped due to toxicology concerns.
Status:
Investigational
Source:
INN:nifuratrone
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Nifuratrone is a nitrofuran which was used for the control of Salmonella choleraesuis in swine. It was also used for the treatment of gonorrhea.
Status:
Investigational
Source:
INN:DIMESONE [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Dimesone is a synthetic glucocorticoid with anti-inflammatory and anti-allergic activity.
Status:
Investigational
Source:
INN:CODOXIME [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Codoxime is a synthetic derivative of an opiate dihydrocodeinone. It differs from dihydrocodeinone by the substitution of a carboxymethyl oxime for the ketonic oxygen at carbon 6 of the dihydrocodeinone molecule. Codoxime has been proposed as an antitussive with prolonged duration of action. In a clinical trial conducted on prisoner volunteers in 1966, it was found that codoxime has a capacity to produce physical dependence of the morphine type.