U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 4361 - 4370 of 6957 results

Status:
Investigational
Source:
NCT00657137: Phase 2 Breast Cancer
(2008)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Status:
Investigational
Source:
NCT00938652: Phase 3 Breast Cancer
(2009)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Iniparib (BSI-201 or 4-iodo-3-nitrosobenzamide) inactivated poly(ADP-ribose) polymerase by zinc ejection from the first zinc finger of this nuclear protein. Iniparib, either alone or in combination with chemotherapy, had significant antitumor activity in preclinical studies in vitro and in vivo. In June 2013, Sanofi dropped the drug after it failed in a phase III trial of patients with squamous non–small-cell lung cancer and a phase II trial in platinum-resistant ovarian cancer.
Status:
Investigational
Source:
INN:TEMELASTINE [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
NCT03291938: Phase 1 Malignant Neoplasms Stated as Primary Lymphoid Haematopoietic
(2018)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
INN:IMILOXAN [INN]
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)


Conditions:

Imiloxan is a highly selective alpha2B adrenoceptor antagonist and was developed for depression in the 1980's. In Phase 1 clinical trials imiloxan dosing led to hypersensitivity reactions; the molecule's development was discontinued.
Status:
Investigational
Source:
JAN:DL-METHYLEPHEDRINE SACCHARINATE [JAN]
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Status:
Investigational
Source:
NCT00210080: Phase 3 Lung Cancer
(2001)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Cycloheximide is an antibiotic produced by fermentation culture of Streptomyces griseus, Streptomyces noursei, Streptomyces albulus, Streptomyces naraensis, or other cycloheximide-producing microorganism. It was first discovered by A. Whiffen et al. in 1946. She observed the activity of the compound against the yeasts and it became known as the first antifungal antibiotic. Cycloheximide has been marketed as a plant fungicide for many years and this use continues mainly against fungal diseases of turf and for powdery mildew on roses. More recently, cycloheximide has been recognized and is being developed as an abscission agent for citrus fruits and olives. Due to significant toxic side effects, including DNA damage, teratogenesis, and other reproductive effects, cycloheximide is generally used only in in vitro research applications, and is not suitable for human use as a therapeutic compound. Cycloheximide is an antimitotic and an inhibitor of the synthesis of both DNA and protein.
Status:
Investigational
Source:
NCT00403702: Phase 2/Phase 3 Retinal Detachment
(2006)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
INN:SALINAZID [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Salinazid (Acozid, Nupasal-213) is an antibacterial agent used primarily as a tuberculostatic. It used to be the treatment of choice for tuberculosis.

Showing 4361 - 4370 of 6957 results